It helps enzymes turn nutrients into energy. It also has antioxidant properties. Since humans can only produce ALA in small amounts, many people turn to supplements to increase their intake. Some claim that ALA may help people lose weight. For example, one study on an animal model found that ALA could improve skeletal muscle energy metabolism, possibly increasing how many calories the body can burn.
However, studies also show that the impact of ALA on weight loss is small. According to a analysis , those taking ALA supplements only lost an average of 1. Some research suggests that ALA may help the body control blood sugar levels and improve cholesterol levels. Research has also shown that it could reduce nerve damage symptoms that are common in people with diabetes, such as numbness, pain, and paralysis.
CRP is an inflammation marker that may indicate chronic inflammation linked to harmful diseases such as diabetes and cancer. According to some research , ALA, because it is a potent antioxidant , may help reduce oxidative stress.
Oxidative stress is one of the primary causes of heart disease. Oxidative stress occurs naturally with age. As well as playing a role in the development of heart disease, it also plays a critical role in brain health and memory loss. Some studies show that ALA may have health benefits including reducing inflammation, aiding weight loss, and lowering the risk of heart disease.
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Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. Anticancer Drugs. Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. Alpha-lipoic acid Dihydrolipoic acid; Lipoic acid; Lipolate; Thiotic acid.
Dietary Sources If you are healthy, your body makes enough alpha-lipoic acid. Alpha Lipoic Acid ALA is not classified as a vitamin, yet is synthesized by the body and is conditionally essential. Alpha lipoic acid benefits include supporting glucose metabloism, and this is perhaps it's best known feature.
Paying attention to the form is important. For example, if your target is healthy glucose metabolism, all oxidized forms S, R, and racemic will have an effect on glucose uptake; however, only the R form interacts with the insulin receptor itself. ALA essentially has two purposes. Primarily, it acts as a co-enzyme in metabolic functions and secondarily to scavenge free radicals. It is also effective in both its oxidized and reduced forms. Many studies use mg of oxidized alpha lipoic acid two to three times per day.
Chronic high dosages of approximately g per day have been shown to increase oxidative damage. This website uses cookies. By using this website, you agree that Schwabe North America, Inc and its affiliates may store cookies on your device. For more information on the cookies we use, Please see our Privacy Policy.
Mitochondria efficiently recycle ALA under normal circumstances. Diabetes Care. Do not use different forms tablets and capsules of alpha-lipoic acid at the same time without medical advice. Using different formulations together increases the risk of an overdose. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra alpha-lipoic acid to make up the missed dose.
Health Topics. Health Tools. Alpha-Lipoic Acid Alpha Lipoic. Reviewed: June 23, Dietary Supplement. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: liver disease; diabetes alpha-lipoic acid can cause low blood sugar ; a thyroid disorder; a thiamine deficiency thiamine is a form of vitamin B ; or if you drink large amounts of alcohol.
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