What makes aspirin a prodrug

Some drug interactions can occur when aspirin is given with other medicines. Aspirin can displace drugs from their plasma binding-sites and in this way may increases the effects of anticoagulant drugs and oral hypoglycaemics. It can also inhibit urate secretion and should be avoided in gout 3. The Reactions The production of aspirin from raw materials can be divided into four separate reactions as shown here:.

Chapter 11 Anti-inflammatory drugs: treatment of arthritis and gout. The non-steroidal anti-inflammatory drugs. Ge Junbo, male, was born in Wulian, Shandong province on Nov. He is the member of Chinese Academy of Sciences, professor and doctoral supervisor.

He is also the designate chairman of the Cardiovascular Disease Branch of Chinese Medical Association, council member of the Cardiovascular Angiography and Interventions Association, international consultant of the American Heart Association.

In Dec. Ge has been engaged in clinical and scientific research work of cardiovascular disease since , and his research area covers the pathogenesis of coronary heart disease, early diagnosis and treatment plan optimization. Click here to find the press release. Discipline: Cardiology and Epidemiology. Neurology and Vascular Neurology. We would like to hear from you and have a chat, and maybe feature you on our podcast.

Please fill in the form below and we will contact you with further information. The Chemistry of Aspirin acetylsalicylic acid. Connect with us. Sign up to be part of the aspirin community and be the first to receive latest information.

Have something to say about aspirin? Contact Us Here. Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. Cancer Res. Non-steroidal anti-inflammatory drugs NSAIDs and breast cancer risk: differences by molecular subtype. Cancer Causes Control. Wang D, Dubois RN. Cyclooxygenase a potential target in breast cancer. Semin Oncol. Howe LR. Inflammation and breast cancer.

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Production of oxymetabolites is not necessarily mediated by cytochrome-P oxygenases: as this report indicates, they may also be formed by interactions, possibly non-enzymatic, with reactive oxygen-derived species generated by inflammatory cells. Reprints and Permissions. Haynes, D. Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites. Agents and Actions 39, 49—58 Download citation.

Received : 16 June Accepted : 07 March Issue Date : May Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

Skip to main content. Search SpringerLink Search. Abstract Aspirin and salicylate are transformed by stimulated human polymorphonuclear leucocytes PMN , likely to be found at inflammatory sites, into both 2,3- and 2,5-dihydroxybenzoates DHB. References [1] J. Google Scholar [2] B. Google Scholar [3] T. Google Scholar [4] C. Google Scholar [5] E. Google Scholar [6] C. Google Scholar [7] S. Google Scholar [8] S. Google Scholar [9] A.

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